Sedentary behavior independently predicts cancer mortality
Replacing sitting time with 30 minutes of activity associated with lower
risk of cancer death

Date:
June 18, 2020
Source:
University of Texas M. D. Anderson Cancer Center
Summary:
In the first study to look at objective measures of sedentary
behavior and cancer mortality, researchers found that greater
inactivity was independently associated with a higher risk of
dying from cancer.



FULL STORY ==========================================================================
In the first study to look at objective measures of sedentary behavior
and cancer mortality, researchers from The University of Texas MD Anderson Cancer Center found that greater inactivity was independently associated
with a higher risk of dying from cancer. The most sedentary individuals
had an 82% higher risk of cancer mortality compared to the least sedentary individuals. An accelerometer was used to measure physical activity,
rather than relying on participants to self-report their activity levels

========================================================================== "This is the first study that definitively shows a strong association
between not moving and cancer death," said Susan Gilchrist, M.D.,
associate professor of Clinical Cancer Prevention and lead author of
the study, published today in JAMA Oncology. "Our findings show that
the amount of time a person spends sitting prior to a cancer diagnosis
is predictive of time to cancer death." Researchers also found that
replacing 30 minutes of sedentary time with physical activity was
associated with a 31% lower risk of cancer death for moderate-intensity activity, such as cycling, and an 8% lower risk of cancer death for light-intensity activity, such as walking.

"Conversations with my patients always begin with why they don't have
time to exercise," said Gilchrist, who leads MD Anderson's Healthy
Heart Program. "I tell them to consider standing up for 5 minutes every
hour at work or taking the stairs instead of the elevator. It might
not sound like a lot, but this study tells us even light activity has
cancer survival benefits." Study design This study involved a cohort
of participants from the nationally representative REGARDS study, which recruited more than 30,000 U.S. adults over the age of 45 between 2003
and 2007 to study long-term health outcomes.

To measure sedentary behavior, 8,002 REGARDS participants who did not have
a cancer diagnosis at study enrollment wore an accelerometer on their hip during waking hours for seven consecutive days. The accelerometer data
was gathered between 2009 and 2013. After a mean follow-up of 5 years,
268 participants died of cancer. Longer duration of sedentary behavior
was independently associated with a greater risk of cancer death.

The study also found that engaging in either light or moderate to vigorous physical activity made a difference. Investigators assessed sedentary
time, light-intensity physical activity (LIPA) and moderate to vigorous physical activity (MVPA) in the same model and found that LIPA and MVPA,
not sedentary behavior, remained significantly associated with cancer mortality.

"From a practical perspective, this means that individuals who replaced
either 10 to 30 minutes of sedentary time with either LIPA or MVPA had
a lower risk of cancer mortality in the REGARDS cohort," Gilchrist said.

The study had several limitations, including a potentially healthier participant sample compared to the full REGARDS cohort and a lack of site- specific cancer data, including type of tumor and treatment.

"Our findings reinforce that it's important to 'sit less and move more'
and that incorporating 30 minutes of movement into your daily life can
help reduce your risk of death from cancer," Gilchrist said. "Our next
step is to investigate how objectively measured sedentary behavior impacts site-specific cancer incidence and if gender and race play a role."

========================================================================== Story Source: Materials provided by University_of_Texas_M._D._Anderson_Cancer_Center. Note: Content may be
edited for style and length.


========================================================================== Journal Reference:
1. Susan C. Gilchrist, Virginia J. Howard, Tomi Akinyemiju, Suzanne
E. Judd,
Mary Cushman, Steven P. Hooker, Keith M. Diaz. Association of
Sedentary Behavior With Cancer Mortality in Middle-aged and Older
US Adults. JAMA Oncology, 2020; DOI: 10.1001/jamaoncol.2020.2045 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2020/06/200618150311.htm

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