Regulation of cancer stemness by the best combination of nanotech and
genetic engineering

Date:
August 17, 2020
Source:
Japan Advanced Institute of Science and Technology
Summary:
Photo-active nanocomplexes are successfully developed. The
nanocomplexes allow spatiotemporal controlling
genetically-engineered cells that are overexpressing
temperature-sensitive membrane proteins. The technology demonstrates
effective cancer elimination and dramatic suppression of cancer
stemness in cells and mice.



FULL STORY ==========================================================================
The development of chemotherapeutic agents with selective anti-cancer activities is increasingly unattractive due to the emergence
of resistance, poor targeting of cancer tissues, and subsequent
metastasis. Among tumor characteristic cell types, cancer stem cells
are increasingly associated with cancer progression and metastasis,
reflecting self-renewal and their propensity to enter the circulation.


========================================================================== Scientists at Japan Advanced Institute of Science and Technology (JAIST)
have created a regulation technology of fatal cancer stemness using
the combination of nanotechnology and genetic engineering called as "photothermogenetics" that allows for effective cancer elimination.

Developed by Associate Professor Eijiro Miyako and his team from JAIST,
photo- active functional nanocarbon complexes, which made of polyethylene glycol (PEG)-modified carbon nanohorns (CNH) with an antibody against
the receptor potential vanilloid family type 2 (TRPV2), showed high
potential as a targeting cancer chemotherapeutic agent.

In fact, the nanocomplexes are effectively heated by biologically
permeable near-infrared light. After application to cancer cells and
mice tumor models, these complexes photo-thermally triggered calcium
influx into target cells overexpressing TRPV2 (temperature-responsive
membrane protein), resulting in increased cancer cell death and effective regulation of cancer stemness. The present experiments warrant further consideration of this novel chemotherapeutic approach using the best combination of nanotechnology and genetic engineering for the treatment
of refractory cancers and control of fatal cancer stemness.


========================================================================== Story Source: Materials provided by Japan_Advanced_Institute_of_Science_and_Technology. Note: Content may
be edited for style and length.


========================================================================== Journal Reference:
1. Yue Yu, Xi Yang, Sheethal Reghu, Sunil C. Kaul, Renu Wadhwa, Eijiro
Miyako. Photothermogenetic inhibition of cancer stemness by near-
infrared-light-activatable nanocomplexes. Nature Communications,
2020; 11 (1) DOI: 10.1038/s41467-020-17768-3 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2020/08/200817123046.htm

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