The six strains of SARS-CoV-2

Date:
August 3, 2020
Source:
Universita` di Bologna
Summary:
The virus causing the COVID-19 pandemic, SARS-CoV-2, presents at
least six strains. Despite its mutations, the virus shows little
variability, and this is good news for the researchers working on
a viable vaccine.



FULL STORY ========================================================================== SARS-CoV-2 mutation rate remains low. Across Europe and Italy, the
most widespread is strain G, while the L strain from Wuhan is gradually disappearing. These mutations, however, do not impinge on the process
of developing effective vaccines.


==========================================================================
The virus causing the COVID-19 pandemic, SARS-CoV-2, presents at least
six strains. Despite its mutations, the virus shows little variability,
and this is good news for the researchers working on a viable vaccine.

These are the results of the most extensive study ever carried out on
SARS-CoV- 2 sequencing. Researchers at the University of Bologna drew
from the analysis of 48,635 coronavirus genomes, which were isolated by researchers in labs all over the world. This study was published in the
journal Frontiers in Microbiology. It was then possible for researchers
to map the spread and the mutations of the virus during its journey to
all continents.

The first results are encouraging. The coronavirus presents little
variability, approximately seven mutations per sample. Common influenza
has a variability rate that is more than double.

"The SARS-CoV-2 coronavirus is presumably already optimized to affect
human beings, and this explains its low evolutionary change," explains
Federico Giorgi, a researcher at Unibo and coordinator of the study. "This means that the treatments we are developing, including a vaccine,
might be effective against all the virus strains." Currently, there
are six strains of coronavirus. The original one is the L strain, that
appeared in Wuhan in December 2019. Its first mutation -- the S strain
-- appeared at the beginning of 2020, while, since mid-January 2020,
we have had strains V and G. To date strain G is the most widespread:
it mutated into strains GR and GH at the end of February 2020.



========================================================================== "Strain G and its related strains GR and GH are by far the most
widespread, representing 74% of all gene sequences we analysed," says
Giorgi. "They present four mutations, two of which are able to change
the sequence of the RNA polymerase and Spike proteins of the virus. This characteristic probably facilitates the spread of the virus." If we
look at the coronavirus map, we can see that strains G and GR are the
most frequent across Europe and Italy. According to the available data,
GH strain seems close to non-existence in Italy, while it occurs more frequently in France and Germany. This seems to confirm the effectiveness
of last months' containment methods.

In North America, the most widespread strain is GH, while in South
America we find the GR strain more frequently. In Asia, where the Wuhan
L strain initially appeared, the spread of strains G, GH and GR is
increasing. These strains landed in Asia only at the beginning of March,
more than a month after their spread in Europe.

Globally, strains G, GH and GR are constantly increasing. Strain S can be
found in some restricted areas in the US and Spain. The L and V strains
are gradually disappearing.

Besides these six main coronavirus strains, researchers identified some infrequent mutations, that, at the moment, are not worrying but should nevertheless be monitored.

"Rare genomic mutations are less than 1% of all sequenced genomes,"
confirms Giorgi. "However, it is fundamental that we study and
analyse them so that we can identify their function and monitor their
spread. All countries should contribute to the cause by giving access
to data about the virus genome sequences." This study was published
in the journal Frontiers in Microbiology with the title "Geographic and
Genomic Distribution of SARS-CoV-2 Mutations." The authors are Daniele Mercatelli and Federico M. Giorgi, both from the Department of Pharmacy
and Biotechnology of the University of Bologna.


========================================================================== Story Source: Materials provided by Universita`_di_Bologna. Note:
Content may be edited for style and length.


========================================================================== Journal Reference:
1. Daniele Mercatelli, Federico M. Giorgi. Geographic and Genomic
Distribution of SARS-CoV-2 Mutations. Frontiers in Microbiology,
2020; 11 DOI: 10.3389/fmicb.2020.01800 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2020/08/200803105246.htm

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