Mouthwashes could reduce the risk of coronavirus transmission, study
shows

Date:
August 10, 2020
Source:
Ruhr-University Bochum
Summary:
Results from cell culture experiments show that commercially
available preparations have an effect on Sars-Cov-2 viruses.



FULL STORY ========================================================================== Sars-Cov-2 viruses can be inactivated using certain commercially
available mouthwashes. This was demonstrated in cell culture experiments
by virologists from Ruhr-Universita"t Bochum together with colleagues from Jena, Ulm, Duisburg-Essen, Nuremberg and Bremen. High viral loads can be detected in the oral cavity and throat of some Covid-19 patients. The use
of mouthwashes that are effective against Sars-Cov-2 could thus help to
reduce the viral load and possibly the risk of coronavirus transmission
over the short term. This could be useful, for example, prior to dental treatments. However, mouth rinses are not suitable for treating Covid-19 infections or protecting yourself against catching the virus.


==========================================================================
The results of the study are described by the team headed by Toni
Meister, Professor Stephanie Pfa"nder and Professor Eike Steinmann from
the Bochum-based Molecular and Medical Virology research group in the
Journal of Infectious Diseases, published online on 29 July 2020. A
review of laboratory results in clinical trials is pending.

Eight mouthwashes in a cell culture test The researchers tested eight mouthwashes with different ingredients that are available in pharmacies
or drugstores in Germany. They mixed each mouthwash with virus particles
and an interfering substance, which was intended to recreate the effect
of saliva in the mouth. The mixture was then shaken for 30 seconds to
simulate the effect of gargling. They then used Vero E6 cells, which are particularly receptive to Sars-Cov-2, to determine the virus titer. In
order to assess the efficacy of the mouthwashes, the researchers also
treated the virus suspensions with cell culture medium instead of the
mouthwash before adding them to the cell culture.

All of the tested preparations reduced the initial virus titer. Three mouthwashes reduced it to such an extent that no virus could be detected
after an exposure time of 30 seconds. Whether this effect is confirmed
in clinical practice and how long it lasts must be investigated in
further studies.

The authors point out that mouthwashes are not suitable for treating
Covid-19.

"Gargling with a mouthwash cannot inhibit the production of viruses in
the cells," explains Toni Meister, "but could reduce the viral load in
the short term where the greatest potential for infection comes from,
namely in the oral cavity and throat -- and this could be useful in
certain situations, such as at the dentist or during the medical care
of Covid-19 patients." Clinical studies in progress The Bochum group
is examining the possibilities of a clinical study on the efficacy of mouthwashes on Sars-Cov-2 viruses, during which the scientists want
to test whether the effect can also be detected in patients and how
long it lasts. Similar studies are already underway in San Francisco;
the Bochum team is in contact with the American researchers.


========================================================================== Story Source: Materials provided by Ruhr-University_Bochum. Original
written by Julia Weiler; translated by Lund Languages. Note: Content
may be edited for style and length.


========================================================================== Journal Reference:
1. Toni Luise Meister, Yannick Bru"ggemann, Daniel Todt, Carina
Conzelmann,
Janis A Mu"ller, Ru"diger Gross, Jan Mu"nch, Adalbert Krawczyk,
Jo"rg Steinmann, Jochen Steinmann, Stephanie Pfaender, Eike
Steinmann.

Virucidal efficacy of different oral rinses against SARS-CoV-2. The
Journal of Infectious Diseases, 2020; DOI: 10.1093/infdis/jiaa471 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2020/08/200810103239.htm

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