Could the cure for IBD be inside your mouth?
A new study describes how poor oral health may worsen gut inflammation


Date:
June 16, 2020
Source:
Michigan Medicine - University of Michigan
Summary:
A new collaborative study reveals that inflammatory bowel disease
(IBD) may be the latest condition made worse by poor oral health
via a clash between the mouth and gut microbiomes.



FULL STORY ========================================================================== While many people put off their regular trips to the dentist, recent
research has shown that the consequences of doing so may go beyond
cavities and root canals. From heart disease to diabetes, poor oral
health is often a reflection of a person's overall health and may even
be the cause of systemic disease.


==========================================================================
A new collaborative study from the U-M Medical and Dental Schools reveals
that inflammatory bowel disease (IBD), which included Crohn's disease
and ulcerative colitis and afflicts an estimated 3 million adults in
the U.S., may be the latest condition made worse by poor oral health.

Nobuhiko Kamada, Ph.D., assistant professor of internal medicine in
the division of gastroenterology, has been studying the gut microbiome
-- the collection of bacteria that are normally present in the gut --
for years. He noted an emerging link in research literature between an overgrowth of foreign bacterial species in the guts of people with IBD -- bacteria that are normally found in the mouth. "I decided to approach
the dental school to ask the question, does oral disease affect the
severity of gastrointestinal diseases?" says Kamada.

The new mouse study, published in Cell, shows two pathways by which oral bacteria appear to worsen gut inflammation.

In the first pathway, periodontitis, the scientific name for gum disease,
leads to an imbalance in the normal healthy microbiome found in the
mouth, with an increase of bacteria that cause inflammation. These disease-causing bacteria then travel to the gut.

However, this alone may not be enough to set off gut inflammation. The
team demonstrated that oral bacteria may aggravate gut inflammation by
looking at microbiome changes in mice with inflamed colons.

"The normal gut microbiome resists colonization by exogenous, or
foreign, bacteria," says Kamada. "However, in mice with IBD, the
healthy gut bacteria are disrupted, weakening their ability to resist disease-causing bacteria from the mouth." The team found that mice with
both oral and gut inflammation had significantly increased weight loss
and more disease activity.

In the second proposed pathway, periodontitis activates the immune
system's T cells in the mouth. These mouth T cells travel to the gut
where they, too, exacerbate inflammation. The gut's normal microbiome
is held in balance by the action of inflammatory and regulatory T cells
that are fine-tuned to tolerate the resident bacteria. But, says Kamada,
oral inflammation generates mostly inflammatory T cells that migrate
to the gut, where they, removed from their normal environment, end up triggering the gut's immune response, worsening disease.

"This exacerbation of gut inflammation driven by oral organisms that
migrate to the gut has important ramifications in emphasizing to patients
the critical need to promote oral health as a part of total body health
and wellbeing," says co-author William Giannobile, DDS, the William K
and Mary Anne Najjar professor of dentistry and chair of the department
of periodontics and oral medicine at the U-M School of Dentistry.

The study has implications for novel treatments for IBD, necessary because
"far too many patients still fail medications, leading to reduced quality
of life and eventual surgery," says study co-author Shrinivas Bishu,
M.D., assistant professor of gastroenterology. "This study importantly
implies that clinical outcomes in IBD may be improved by monitoring oral inflammation -- an intriguing concept."

========================================================================== Story Source: Materials provided by
Michigan_Medicine_-_University_of_Michigan. Note: Content may be edited
for style and length.


========================================================================== Journal Reference:
1. Sho Kitamoto, Hiroko Nagao-Kitamoto, Yizu Jiao, Merritt
G. Gillilland,
Atsushi Hayashi, Jin Imai, Kohei Sugihara, Mao Miyoshi, Jennifer C.

Brazil, Peter Kuffa, Brett D. Hill, Syed M. Rizvi, Fei Wen,
Shrinivas Bishu, Naohiro Inohara, Kathryn A. Eaton, Asma Nusrat,
Yu L. Lei, William V. Giannobile, Nobuhiko Kamada. The Intermucosal
Connection between the Mouth and Gut in Commensal Pathobiont-Driven
Colitis. Cell, 2020; DOI: 10.1016/j.cell.2020.05.048 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2020/06/200616113927.htm

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