Brain waves can be used to predict future pain sensitivity

Date:
August 6, 2020
Source:
University of Birmingham
Summary:
Rhythms produced by the brain can reliably be used to predict how
sensitive we are to pain, new research shows.



FULL STORY ========================================================================== Rhythms produced by the brain can reliably be used to predict how
sensitive we are to pain, new research shows.


==========================================================================
The living brain is constantly producing regular rhythmic patterns of
activity, which can be compared to musical notes. Scientists at the
University of Birmingham in the UK, and the University of Maryland
School of Dentistry in the US, have successfully demonstrated that one particularly prevalent pattern of brain activity, called alpha waves,
strongly relates to the body's susceptibility or resilience to pain.

Alpha waves oscillate between 8-14 Hz, with the peak frequency varying
across individuals. The researchers demonstrated how a measurement of
an individual's alpha wave frequency can be used as a reliable pain
indicator.

The study, led by graduate student Andrew Furman and published in the
journal Cerebral Cortex, suggests that these alpha waves could be used
to help clinicians understand how susceptible a patient to experience
severe pain post- surgery.

Dr David Seminowicz of the University of Maryland School of Dentistry
is co- author of the study. He explains: "Understanding a patient's
pain sensitivity could be really important in, for example, deciding
whether an elective procedure is the best option or planning post-surgery rehabilitation. Pain management drugs or techniques such as mindfulness meditation can also be used before surgery to help minimise pain."
Dr Ali Mazaheri, from the University of Birmingham's School of Psychology
and Centre for Human Brain Health and also co-author of the study, adds: "Severe pain following surgery is often also a good indicator of whether
or not a patient is likely to go on to develop chronic pain. Understanding whether or not a person is at high risk of developing these symptoms
will help patients and clinicians make better informed choices about the
best course of treatment." Alpha waves are just one type of electrical activity going on continually in our brains. They're thought to be most
present when a person is awake, but maybe idle. In our sensory systems,
their presence signals that a particular part of the system has 'closed
down' for processing. When the waves are reduced, that system is ready
to start working again.



==========================================================================
For most people these oscillations occur continuously in the brain at frequencies of between 8-14Hz. Previous research carried out by the
group showed that people with alpha waves occurring at the higher end
of this scale were more resilient to pain, while those at the lower end
were more susceptible.

In this experiment, the team wanted to find out whether, by taking an
initial measurement of the subject's alpha waves, it was possible to
predict their reaction to pain.

The researchers tested 61 healthy participants, both men and women, aged between 21 and 42. Alpha waves were measured in each participant using electroencephalography (EEG) and then participants were each exposed to
two different pain episodes. In the first of these a cream containing
capsaicin - - the active ingredient in chilli peppers -- was applied to
produce sensitised skin; in the second participants underwent repeated applications of heat. After eight weeks, the subjects returned to repeat
the experiment.

The results showed that measuring alpha waves did give a reliable
indication of a person's susceptibility or resilience to pain. These
results were reliable both in the initial assessment and in the eight-week follow up.

In Birmingham, these principles are already being tested in partnership
with clinicians at the Heartlands and Queen Elizabeth Hospitals. Dr
Mazaheri is leading a study investigating the use of alpha waves and
the pain experience of lung cancer patients undergoing lung biopsies.

"We know that lung surgery is a particularly painful procedure, with
between 40 and 60 per cent of patients going on to develop debilitating
pain after surgery," explains Dr Mazaheri. "By predicting which patients
are likely to develop this pain, we can start to explore other options,
such as radiotherapy, or make sure that intensive rehabilitation
programmes are in place to support those patients through recovery."
The team is currently actively seeking funding to continue this work.


========================================================================== Story Source: Materials provided by University_of_Birmingham. Note:
Content may be edited for style and length.


========================================================================== Journal Reference:
1. David A Seminowicz, Ali Mazaheri, Shuo Chen, Jing Zhang, Michael L
Keaser, Mariya Prokhorenko, Andrew J Furman. Sensorimotor
Peak Alpha Frequency Is a Reliable Biomarker of Prolonged Pain
Sensitivity. Cerebral Cortex, 2020; DOI: 10.1093/cercor/bhaa124 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2020/08/200806111906.htm

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