Exercise induces secretion of biomarkers into sweat
A new study shows that in addition to blood, endurance exercise induces changes in sweat biomolecule levels

Date:
August 12, 2020
Source:
University of Jyva"skyla" - Jyva"skyla"n yliopisto
Summary:
The aim was to reveal the potential of microRNAs in sweat
extracellular vesicles in monitoring exercise performance.



FULL STORY ==========================================================================
A new study shows that in addition to blood, endurance exercise induces
changes in sweat biomolecule levels. These findings lay the groundwork
for the development of future noninvasive exercise monitoring systems
that utilize sweat as a biomarker source.


========================================================================== Sweating is an important part of thermoregulation during exercise,
yet the potential for sweat as a biomarker source has not been
established. Currently, the key limiting steps of using sweat as
a biomarker source for exercise monitoring are the low abundance of
biomarkers and variation in the volume of sweat in different environments
and in different persons.

"Previously, sweat has been utilized in the diagnostics of certain
diseases, such as cystic fibrosis. In addition, several drugs are secreted
into sweat, enabling detection of the drug from sweat instead of blood," explains postdoctoral researcher Sira Karvinen from the Gerontology
Research Center and Faculty of Sport and Health Sciences, University of Jyva"skyla", Finland.

New finding: Extracellular vesicles in sweat contain microRNAs Evaporation
of sweat from the skin surface lowers body temperature preventing
overheating of the body in hot environments as well as during strenuous exercise. Although sweat is a natural by-product of exercise and has
been studied for several decades, a role for it as a biomarker source
in the field of exercise has not been established.

It has previously been observed that similarly as blood and other body
fluids, sweat contains extracellular vesicles. Extracellular vesicles
are composed of a lipid bilayer and a core containing transported signal molecules, which cells release to facilitate communication between
cells and tissues. A novel finding of the current study was that sweat extracellular vesicles contain microRNA molecules. MicroRNAs regulate
several biological processes and have been identi?ed as essential
mediators in exercise adaptations. Previously, endurance exercise has
shown to change the level of several microRNAs in blood.



==========================================================================
"In our study we examined how elevation in body temperature induced by
sauna and endurance exercise protocols affect the abundance of microRNAs
in sweat and serum extracellular vesicles. Endurance exercise protocols
were carried out with a bicycle ergometer," says Urho Kujala, Professor
of sports and exercise medicine, from the Faculty of Sport and Health
Sciences, University of Jyva"skyla", Finland. "Our aim was to reveal
the potential of microRNAs in sweat extracellular vesicles in monitoring exercise performance." In the present study sweat samples were harvested
from the study subjects during sauna bathing and during three different endurance exercise tests: a maximal aerobic capacity test and high and
low intensity endurance exercise tests. Sweat was collected during the
entire duration of each test from both arms and blood samples were taken
before and after each test.

Sweat may be used as a biomarker source for exercise monitoring in the
future The present study showed that the abundance of certain microRNAs
changed in response to exercise of different intensity in sweat
extracellular vesicles. In particular, the high-intensity endurance
exercise test induced an increase in the studied microRNAs in serum
and sweat.

"Our study is the first to show that sweat possesses unique miR carrier
content that is different from that observed in blood," Karvinen
explains. "This may partly explain the observation that sweat and
serum microRNA levels are not similar." Based on the results of the
present study, sweat has a potential to serve as a biomarker source for
future exercise monitoring systems. However, sweat possesses a unique
miR carrier content that should be taken into account when planning
analyses from sweat as a substitute for serum. There are currently no commercially available sweat-based monitoring systems, as first there is
a need to invent new technologies to robustly detect very small amounts
of biomarkers.

The present project was a collaborative study between the Universities
of Jyva"skyla" and Oulu and was funded by Business Finland.


========================================================================== Story Source: Materials provided by University_of_Jyva"skyla"_-_Jyva"skyla"n_yliopisto. Note: Content may
be edited for style and length.


========================================================================== Journal Reference:
1. Sira Karvinen, Tero Sieva"nen, Jari E. Karppinen, Pekka Hautasaari,
Genevie`ve Bart, Anatoliy Samoylenko, Seppo J. Vainio, Juha
P. Ahtiainen, Eija K. Laakkonen, Urho M. Kujala. MicroRNAs
in Extracellular Vesicles in Sweat Change in Response to
Endurance Exercise. Frontiers in Physiology, 2020; 11 DOI:
10.3389/fphys.2020.00676 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2020/08/200812144057.htm

--- up 4 weeks, 1 hour, 55 minutes
* Origin: -=> Castle Rock BBS <=- Now Husky HPT Powered! (1337:3/111)