Susceptibility to carcinogens varies due to genetics

Date:
June 16, 2020
Source:
University of Hawaii at Manoa
Summary:
A new study looks into how and why certain individuals develop
cancer and others do not.



FULL STORY ==========================================================================
A new study led by the University of Hawaii Cancer Center looks into
how and why certain individuals develop cancer and others do not. The
research was published in Nature Reviews Cancer. In addition to lead
author Michele Carbone and co-author Haining Yang, collaborators include
top cancer researchers, including a Nobel Laureate, and several members
of the U.S. and European Academy of Sciences.


==========================================================================
In the publication, "Tumour predisposition and cancer syndromes as models
to study gene-environment interactions," Carbone and collaborators
discuss recent evidence indicating that cancer most often results
from the interaction between an individual's genetics and exposure to environmental carcinogens. They emphasize that the risk of developing
cancer upon exposure to carcinogens varies due to gene mutations that
can make certain individuals much more susceptible than others.

"By identifying those who carry genetic mutations, we can implement more effective prevention and early detection strategies targeting those who
are most vulnerable, and thus, we have a much greater impact in saving
lives from cancer," said Carbone.

This is the first time that the role of gene-environment interaction in
cancer is being discussed at this level of molecular detail by some of the
top scientists in the world. Several of the advancements in this field of research were made possible by Carbone and collaborators' discovery of
the "BAP1 cancer syndrome," a disease that allows researchers to study
and elucidate the mechanisms that regulate gene-environment interaction
in causing cancer.

"This important 'Perspective' article highlights some of the most
cutting-edge studies on how genes and environmental factors interact in
causing cancer, which is a critical research topic that needs people's attention," said Yang.

"This comprehensive publication was made possible thanks to the support
of Barry and Virginia Weinman of the Weinman Foundation, who have played
a very significant role in advancing innovations in cancer research,"
said Carbone.

"The Weinmans generously funded meetings at the UH Cancer Center, allowing
the co-authors to meet and discuss the topic at hand. As revealed by
this publication, their contributions continue to tremendously impact and enhance cancer research, not only in the state of Hawai'i, but nationally
and internationally as well."

========================================================================== Story Source: Materials provided by University_of_Hawaii_at_Manoa. Note: Content may be edited for style and length.


========================================================================== Journal Reference:
1. Michele Carbone, Sarah T. Arron, Bruce Beutler, Angela Bononi,
Webster
Cavenee, James E. Cleaver, Carlo M. Croce, Alan D'Andrea, William D.

Foulkes, Giovanni Gaudino, Joanna L. Groden, Elizabeth P. Henske,
Ian D.

Hickson, Paul M. Hwang, Richard D. Kolodner, Tak W. Mak, David
Malkin, Raymond J. Monnat, Flavia Novelli, Harvey I. Pass,
John H. Petrini, Laura S. Schmidt, Haining Yang. Tumour
predisposition and cancer syndromes as models to study
gene-environment interactions. Nature Reviews Cancer, 2020; DOI:
10.1038/s41568-020-0265-y ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2020/06/200616100825.htm

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