Gut microbiome plays important role in sleep regulation
Transplanted bacteria from sleep-apnea mice caused sleep changes in
recipient mice

Date:
September 23, 2020
Source:
University of Missouri-Columbia
Summary:
Obstructive sleep apnea (OSA) affects more than one billion people
worldwide. Evidence suggests OSA can alter the gut microbiome (GM)
and may promote OSA-associated co-morbidities, including diabetes,
hypertension and cognitive problems. Researchers have discovered
how OSA- related sleep disturbances affect the gut microbiome in
mice and how transplanting those gut bacteria into other mice can
cause changes to sleep patterns in the recipient mice.



FULL STORY ========================================================================== Obstructive sleep apnea (OSA) is a chronic sleep condition affecting
more than one billion people worldwide. Evidence suggests OSA can alter
the gut microbiome (GM) and may promote OSA-associated co-morbidities, including diabetes, hypertension and cognitive problems. Researchers
from the University of Missouri School of Medicine and MU Health Care
have discovered how OSA- related sleep disturbances affect the gut
microbiome in mice and how transplanting those gut bacteria into other
mice can cause changes to sleep patterns in the recipient mice.


========================================================================== David Gozal, MD, the Marie M. and Harry L. Smith Endowed Chair of
Child Health at the MU School of Medicine, said the study shows the
gut microbiome plays a major role in sleep regulation. This ultimately
could translate into treatments that target the gut microbiome in humans
with OSA.

"By manipulating the gut microbiome, or the byproducts of the gut
microbiota, we would be in a position to prevent or at least palliate
some of the consequences of sleep apnea," said Gozal, the lead author
of the study. "For example, if we combine continuous positive airway
pressure (CPAP) with customized probiotics that change the patient's
gut microbiome, we might be able to eliminate some of the tiredness and
fatigue and reduce the likelihood of the comorbidities associated with
OSA that affect cognition, memory, cardiovascular disease or metabolic dysfunction. If we can do any one of those things, then this is a major movement forward in the way we treat OSA." The study exposed male mice
to either room air or intermittent hypoxia -- a condition in which the
body doesn't get enough oxygen -- designed to mimic OSA.

After six weeks, researchers collected fecal material from all of the
rodents.

A third group of mice was divided up and given either a fecal transplant
from the mice breathing room air or those exposed to intermittent
hypoxia. The transplanted mice underwent sleep recordings for three
consecutive days.

Researchers found the mice who received transplants from the intermittent hypoxia group slept longer and slept more often during their normal
period of wakefulness, suggesting increased sleepiness.

"This is the first study that evaluated sleep in nai"ve mice subjected to
a fecal microbiome transplant from mice exposed to intermittent hypoxia,"
Gozal said. "The fecal microbiome analysis showed profile differences
between the mice transplanted from intermittent hypoxia donor mice
versus those exposed to room air, indicating that the transplant altered
the GM of the recipient mice." Emerging evidence suggests the GM can
influence health and sleep quality through the brain-gut microbiome
axis (BGMA). The next step is to study the mechanism involved in the relationship between the brain and the gut to determine how changes in
the gut microbiome can affect sleep structure and, in turn, how OSA can contribute to co-morbidities.


========================================================================== Story Source: Materials provided by University_of_Missouri-Columbia. Note: Content may be edited for style and length.


========================================================================== Journal Reference:
1. Mohammad Badran, Abdelnaby Khalyfa, Aaron Ericsson, David
Gozal. Fecal
microbiota transplantation from mice exposed to chronic intermittent
hypoxia elicits sleep disturbances in nai"ve mice. Experimental
Neurology, 2020; 334: 113439 DOI: 10.1016/j.expneurol.2020.113439 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2020/09/200923124804.htm

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