Hydrogel mimics human brain with memorizing and forgetting ability


Date:
July 27, 2020
Source:
Hokkaido University
Summary:
Researchers have found a soft and wet material that can memorize,
retrieve, and forget information, much like the human brain.



FULL STORY ========================================================================== Hokkaido University researchers have found a soft and wet material that
can memorize, retrieve, and forget information, much like the human
brain. They report their findings in the journal Proceedings of the
National Academy of Sciences (PNAS).


==========================================================================
The human brain learns things, but tends to forget them when the
information is no longer important. Recreating this dynamic memory
process in humanmade materials has been a challenge. Hokkaido University researchers now report a hydrogel that mimics the dynamic memory function
of the brain: encoding information that fades with time depending on
the memory intensity.

Hydrogels are flexible materials comprised of a large percentage of water
-- in this case about 45% -- along with other chemicals that provide a scaffold-like structure to contain the water. Professor Jian Ping Gong, Assistant Professor Kunpeng Cui, and their students and colleagues
in Hokkaido University's Institute for Chemical Reaction Design and
Discovery (WPI-ICReDD) are seeking to develop hydrogels that can serve biological functions.

"Hydrogels are excellent candidates to mimic biological functions because
they are soft and wet like human tissues," says Gong. "We are excited
to demonstrate how hydrogels can mimic some of the memory functions of
brain tissue." In this study, the researchers placed a thin hydrogel
between two plastic plates; the top plate had a shape or letters cut out, leaving only that area of the hydrogel exposed. For example, patterns
included an airplane and the word "GEL." They initially placed the gel in
a cold water bath to establish equilibrium. Then they moved the gel to
a hot bath. The gel absorbed water into its structure causing a swell,
but only in the exposed area. This imprinted the pattern, which is like
a piece of information, onto the gel. When the gel was moved back to
the cold water bath, the exposed area turned opaque, making the stored information visible, due to what they call "structure frustration." At
the cold temperature, the hydrogel gradually shrank, releasing the water
it had absorbed. The pattern slowly faded. The longer the gel was left
in the hot water, the darker or more intense the imprint would be, and therefore the longer it took to fade or "forget" the information. The
team also showed hotter temperatures intensified the memories.

"This is similar to humans," says Cui. "The longer you spend learning
something or the stronger the emotional stimuli, the longer it
takes to forget it." The team showed that the memory established
in the hydrogel is stable against temperature fluctuation and large
physical stretching. More interestingly, the forgetting processes can
be programmed by tuning the thermal learning time or temperature. For
example, when they applied different learning times to each letter of
"GEL," the letters disappeared sequentially.

The team used a hydrogel containing materials called polyampholytes or
PA gels.

The memorizing-forgetting behavior is achieved based on fast water
uptake and slow water release, which is enabled by dynamic bonds in the hydrogels. "This approach should work for a variety of hydrogels with
physical bonds," says Gong.

"The hydrogel's brain-like memory system could be explored for some applications, such as disappearing messages for security," Cui added.


========================================================================== Story Source: Materials provided by Hokkaido_University. Note: Content
may be edited for style and length.


========================================================================== Journal Reference:
1. Elaine Guo, Yuki Ishii, James Mueller, Anjana Srivatsan, Timothy
Gahman,
Christopher D. Putnam, Jean Y. J. Wang, and Richard
D. Kolodner. FEN1 endonuclease as a therapeutic target for human
cancers with defects in homologous recombination. PNAS, 2020 DOI:
10.1073/pnas.2009237117 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2020/07/200727154203.htm

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